WASP-WIP-DOCK8 Publications

Wilkie, H., Janssen, E., Levya-Castillo, M., and Geha, R.S. DOCK8 expression in T regulatory cells maintains their stability and limits skin contact hypersensitivity. J. Invest. Derm. S0022-202X(20)32273-9. 2020. PMID: 33171169. DOI: 10.1016/j.jid.2020.09.027.

Janssen, E., Tohme, M., Butts, J., Giguere, S., Sage, P.T., Planas, F., Kam, C., Milin, E., Sobh, A., Al-Tamemi, S., Luscinskas, F.W., Batista, F., and Geha, R.S. DOCK8 is essential for LFA-1 dependent positioning of T follicular helper cells in germinal centers. JCI Insight. 5(15):e134508. 2020. PMID: 32573493. PMCID: PMC7455063. DOI: 10.1172/jci.insight.134508.

Kumari, S., Mak, M., Poh, Y., Melo, M., Tohme, M., Janssen, E., Kamm, R., Geha, R.S., and Irvine, D.J. Cytoskeletal tension actively sustains the migratory T-cell synaptic contact EMBO Journal 39: e102783, 2020. PMID: 31894880. PMCID: PMC7049817. 

Janssen, E., Tohme, M., Ullas, S., T Barrera, V., Tas, J.M., Castillo-Rama, M., Bronson, R.T.,   Usmani, S.M  , Irvine D. J., Mempel, T.R., and Geha, R.S. DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Treg cells. JCI Insight. JCI Insight. 2(19:e94298, 2017.

Janssen, E., Hedayat, M., Leick, M., Tohme, M., Kumari, S., Ramesh, N., Massaad, M., Ullas, S., Azcutia Criado, V., Goodnow, C.C., Randall, K.L., Hu, K., Cox, D., Hartwig, J., Irvine, D.J., Luscinskas, F.W., and Geha, R.S. WIP links DOCK8 to WASP and the actin cytoskeleton. J. Clin. Invest. 126:3837-3851, 2016. doi: 10.1172/JCI85774.

Janssen, E., Henner, M., Ullas, S., Bannock, J.M., Massad, C., Menard, L., Barlan, I., Lefranc, G., Su, H., Dasouki, M., Rezaei, N., Al-Herz, W., Keles, S., Chatila, T., Geha, R.S. *, and E. Meffre, E* DOCK8 deficient patients have a breakdown in peripheral B cell tolerance and defective regulatory T cells. *Equal contributing senior author J. All. Clin. Immunol. 134:1365-7, 2014.

Massaad, M., Oyoshi, M., Koduru, S., Kane, J., Alcaide, P., Nakamura, F., Ramesh, N., Luscinskas, W., Hartwig, J., and Geha, R.S.  Binding of WIP to actin is essential for T cell actin cytoskeleton integrity and tissue homing. Molecular and Cellular Biology 34:4343-54, 2014.

Ramesh, N., Massaad, M., Kumar, L., Koduru, S., Sashara, Y., Anton, I., Bhasin, M., Libermann, T., and Geha, R.S. Binding of the WASP/N-WASP interacting protein WIP to actin regulates   focal adhesion assembly and adhesion. Molecular and Cellular Biology. 34: 2600-10, 2014.

Jabara H., MacDonald D, Janssen, E., Massaad, M. J. Ramesh, N., Borzutzky, A., Rauter, I. Benson, H. Schneider, L., Baxi, S., Rechter, M., Notarangelo, L., Wakim, R., Dbaibo, G. Dasouki, M., Al-Herz, W., Barlan, I, Baris, S., Kutukculer, N., Ochs, H., Plebani, A., Kanariou, M, Lefranc, G., Reisli, I., Fitzgerald, K., Golenbock, D., Manis D., Keles, S, Baris, S., Ceja, R., Chatila, T., and R.S. Geha DOCK8 functions as an adaptor that links TLR/MyD88 signaling to B cell activation. Nature Immunology. 13: 612, 2012.

Lanzi, G., Moratto, D., Vairo, D., Masneri S., Delmonte, O., Parolini S., Tabellini, G., Tovo, P., Silvana Martino, S. Pessach, I., Massaad, M., Ramesh, N., Plebani, A., Notarangelo, L. D., Geha, R.S.*, and S. Giliani A novel primary immunodeficiency due to deficiency in the WASP interacting protein WIP. * Equal contributing senior author. J. Exp. Med. 209:29-34, 2012.

Massaad M. J., Ramesh, N., LeBras, S, Giliani, S., Notarangelo, L.D., Al-Herz, W., Notarangelo, L. D., and R.S. Geha. A WIP peptide restores WASP levels and actin cytoskeleton reorganization in patients with WAS mutations that disrupt WIP binding J. All. Clin. Immunol. 127:998-1005, 2011.​

Le Bras, S., Massaad, M., Kumar, L., Oyoshi, M., Koduru, S., Hartwing J., and R. S. Geha.  WIP is critical for T cell responsiveness to IL-2. Proc. Nat. Acad. Sci. USA. 106:7519-24, 2009.

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