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WASP-WIP-DOCK8 Publications

​Massaad, M.J. Cangemi, B., Al-Herz, W., LeFranc, G., Freeman, A., Baxi, S., Keles, S., Metin, S., Dasouki, M., Sobh, A., Kanariou, M., Al-Sukaiti, N., Ozen, A., Ochs, H., Chatila, T.A., Manis J.P., and Geha, R.S. DOCK8 and STAT3 dependent inhibition of IgE isotype switching by TLR9 ligation in human B cells. Clinical Immunology.  183:263-265, 2017. doi: 10.1016/j.clim.2017.08.020. PMID: 28882618

Janssen, E., Tohme, M., Ullas, S., T Barrera, V., Tas, J.M., Castillo-Rama, M., Bronson, R.T.,   Usmani, S.M  , Irvine D. J., Mempel, T.R., and Geha, R.S. DOCK8 enforces immunological tolerance by promoting IL-2 signaling and immune synapse formation in Treg cells. JCI Insight. JCI Insight. 2(19:e94298, 2017  

Janssen, E., Hedayat, M., Leick, M., Tohme, M., Kumari, S., Ramesh, N., Massaad, M., Ullas, S., Azcutia Criado, V., Goodnow, C.C., Randall, K.L., Hu, K., Cox, D., Hartwig, J., Irvine, D.J., Luscinskas, F.W., and Geha, R.S. WIP links DOCK8 to WASP and the actin cytoskeleton. J. Clin. Invest. 126:3837-3851, 2016. doi: 10.1172/JCI85774.

Keppler, S., Gasparrini, F., Burbage, M., Frederico, B., Geha, RS. Way, M., Bruckbauer, A.,  Batista, FD. WIP deficiency uncovers the role of the co-receptor CD19 as a generic hub for PI3 Kinase signalling in B cells. Immunity. S1074-7613: 389-391, 2015

Janssen, E., Henner, M., Ullas, S., Bannock, J.M., Massad, C., Menard, L., Barlan, I., Lefranc, G., Su, H., Dasouki, M., Rezaei, N., Al-Herz, W., Keles, S., Chatila, T., Geha, R.S. *, and E. Meffre, E* DOCK8 deficient patients have a breakdown in peripheral B cell tolerance and defective regulatory T cells. *Equal contributing senior author J. All. Clin. Immunol. 134:1365-7, 2014.

Massaad, M., Oyoshi, M., Koduru, S., Kane, J., Alcaide, P., Nakamura, F., Ramesh, N., Luscinskas, W., Hartwig, J., and Geha, R.S.  Binding of WIP to actin is essential for T cell actin cytoskeleton integrity and tissue homing. Molecular and Cellular Biology 34:4343-54, 2014.

Ramesh, N., Massaad, M., Kumar, L., Koduru, S., Sashara, Y., Anton, I., Bhasin, M., Libermann, T., and Geha, R.S. Binding of the WASP/N-WASP interacting protein WIP to actin regulates   focal adhesion assembly and adhesion. Molecular and Cellular Biology. 34: 2600-10, 2014

Jabara H., MacDonald D, Janssen, E., Massaad, M. J. Ramesh, N., Borzutzky, A., Rauter, I. Benson, H. Schneider, L., Baxi, S., Rechter, M., Notarangelo, L., Wakim, R., Dbaibo, G. Dasouki, M., Al-Herz, W., Barlan, I, Baris, S., Kutukculer, N., Ochs, H., Plebani, A., Kanariou, M, Lefranc, G., Reisli, I., Fitzgerald, K., Golenbock, D., Manis D., Keles, S, Baris, S., Ceja, R., Chatila, T., and R.S. Geha DOCK8 functions as an adaptor that links TLR/MyD88 signaling to B cell activation. Nature Immunology. 13: 612, 2012

Lanzi, G., Moratto, D., Vairo, D., Masneri S., Delmonte, O., Parolini S., Tabellini, G., Tovo, P., Silvana Martino, S. Pessach, I., Massaad, M., Ramesh, N., Plebani, A., Notarangelo, L. D., Geha, R.S.*, and S. Giliani A novel primary immunodeficiency due to deficiency in the WASP interacting protein WIP. * Equal contributing senior author. J. Exp. Med. 209:29-34, 2012   

Massaad M. J., Ramesh, N., LeBras, S, Giliani, S., Notarangelo, L.D., Al-Herz, W., Notarangelo, L. D., and R.S. Geha. A WIP peptide restores WASP levels and actin cytoskeleton reorganization in patients with WAS mutations that disrupt WIP binding J. All. Clin. Immunol. 127:998-1005, 2011.​

Koduru, S., Massaad, M.,  , N., LeBras, S., Kumar, L., Ozcan, E., Oyoshi, Kaku, M., Fujiwara, Y., Kremer, L., King, S., Fuhlbrigge, R., Sage, P., Carman, C., Alcaide, P., Luscinskas, F.W., and Geha, R. S.  CIP4 is essential for integrin dependent T cell trafficking. Proc. Nat. Acad. Sci. USA. 107:16252-6, 2010.

Le Bras, S., Massaad, M., Kumar, L., Oyoshi, M., Koduru, S., Hartwing J., and R. S. Geha.  WIP is critical for T cell responsiveness to IL-2. Proc. Nat. Acad. Sci. USA. 106:7519-24, 2009.

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