Atopic Dermatitis Publications

Leyva-Castillo, J.M., Yoon, J., Geha, R.S. IL-22 promotes antigen driven airway inflammation in epicutaneously-sensitized mice. J. All. Clin. Immunol. In Press.

Malhotra, N., Leyva-Castillo, M., Jhadav, U., Barriero, O., Kam, C., O’Neill, N. K., Meylan, ., Chambon, P., von Andrian, U., Siegel , R., Wang, E., Shivdasani, R., Geha, R.S. Retinoic Acid Related Receptor Orphan Receptor a (RORa) expressing T regulatory cells restrain  type-2 cutaneous allergic inflammation. Science Immunology. 3: 21, 2018. pii: eaao6923. doi: 10.1126/sciimmunol.aao6923.

Malhotra, N., Yoon, J., Leyva-Castillo, J.M., Galand, C., Archer, N., Miller, L.S., and Geha, R.S. IL-22 released by TCRg/d cells restricts Staphylococcus aureus colonization of mechanically injured skin. J. All. Clin. Immunol  138(4):1098-1107, 2016.

Galand, C., Leyva-Castillo, J.M., Yoon, J., Han, A., Lee, M.S., McKenzie, A., Stassen, M., Oyoshi, M.K. and Geha, R.S. IL-33 promotes food anaphylaxis in epicutaneously sensitized mice by targeting mast cells. J. All. Clin. Immunol. 2016 Jun 2. pii: S0091-6749(16)30369-4. doi: 10.1016/j.jaci.2016.03.056.

Yoon, J., Kim H.Y#., Leyva-Castillo, M. #, Wang, G., Galand, C., Kumar, L., J.M., Leisten, S., Oyoshi, M., He, R., Terhorst, C., Chervonsky, A., Murphy, G., Oppenheim, J.J., Kuchroo, V.K., Umetsu, D.T., Malefyt, Rde, W., Van Den Brink, M.R., and Geha, R.S. Interleukin-23 induced by endogenous TLR4 ligands in keratinocytes programs skin dendritic cells to drive an IL-22 response to epicutaneous sensitization. J.Exp. Med. # Equal contribution 2016 Sep 19;213(10):2147-66. doi: 10.1084/jem.20150376.

Oyoshi, M., Lewis, C.N., Beaupre, J., Venturelli, N., Zeigler. S. McKenzie, A and Geha, R.S. IL-33 and TSLP promotes the dissemination of cutaneously inoculated vaccinia virus. J. All. Clin. Immunol.  135: 1511-18, 2015.

Bartnikas, L.M., M., Leisten, S., Janssen, E., Oettgen, H., Lewis, C. N., Austen, K.F., Gurish, M.F., Schulte, S., Hornick, S., Geha, R. S. * and M. Oyoshi.  Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food anaphylaxis. Equal contributing senior author. J. All. Clin. Immunol. J. All. Clin. Immunol. 131: 451-460, 2013.

Oyoshi, M., He, R Li, Y., Mondal, S., Yoon, J., Afshar, R., Chen, M., Lee, D. M., Luo, H.R., Luster, A., Cho, J.S., Miller, L.S., Larson, A., Murphy, G. and R. S. Geha LTB4  driven neutrophil recruitment to the skin is essential for allergic skin inflammation. Immunity. 37:747-58, 2012.

Oyoshi, M., He, R., Kanaoka, Y., ElKhal, A., Kawamoto, S., Calamito, M., Lewis, C. N., Austen, K.F., and R. S. Geha. Eosinophil-derived LTC4 signals via CysLT2R to promote skin thickening and collagen deposition in a mouse model of allergic skin inflammation. Proc Natl Acad Sci U S A. 109:4992-7, 2012.

Oyoshi, M., ElKhal, A., Scott, J. E., Wurbel, M-A., Campbell J. and R. S. Geha Epicutaneous antigen challenge of orally sensitized mice  redirects antigen specific a4b7 gut homing T cells to the skin. J.  Clin. Investigation. 121: 2210-20, 2011.

Oyoshi, M., and R. S. Geha. Mechanical injury polarizes skin dendritic cells to elicit a Th2 response by inducing cutaneous TSLP expression. J. All. Clin. Immunol. 126: 976-984, 2010.

He, R., Oyoshi, M, Wang, JYT, Hodge, M., Jin, H., and Geha, R.S. The prostaglandin D2 receptor CRTH2 is important for allergic skin inflammation following epicutaneous antigen challenge.  J. All. Clin. Immunol. . 126: 784-790, 2010.

Oyoshi, M., ElKhal, A., Kumar, L., Scott, J. E., Koduru, S., He, R., Leung, D.Y.M., Howell, M.D., Oettgen. H.C., Murphy, G.F., and R. S. Geha. Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response Proc. Nat. Acad. Sci. USA. 106:14954-9, 2009.

Oyoshi, M., Murphy. G, and R. S. Geha. Filaggrin deficient mice exhibit Th17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen. 124:485-93, 493  J. All. Clin. Immunol., 2009.

Le Bras, S., Massaad, M., Kumar, L., Oyoshi, M., Koduru, S., Hartwing J., and R. S. Geha.  WIP is critical for T cell responsiveness to IL-2. Proc. Nat. Acad. Sci. USA. 106:7519-24, 2009.

Jin, H, Oyoshi, M., Mathias, C., Young, D., Collins, M., Grusby, M., Wenzel, J., Bieber, T., Bianchi, T., Boes, M., Oettgen, H.C and R. S. Geha.  IL-21R is essential for the migration of dendritic cells from skin to draining lymph nodes and for the immune response to epicutaneous sensitization. J. Clin. Invest. 119; 47-60, 2009.

He, R., Oyoshi, M., Garibyan, L., Kumar, L., Ziegler,. S. F. and R. S. Geha. TSLP acts on infiltrating effector T cells to drive allergic skin inflammation. Proc. Nat. Acad. Sci. USA. 105:11875-8, 2008.

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