Atopic Dermatitis Publications

Levya-Castillo, J.M., Das, M., Yoon, Y., Galand, C., and Geha R.S. Mast cell-derived IL-13 downregulates IL-2 production by skin dendritic cells to inhibit the Th1 response to cutaneous antigen exposure. J. All. Clin. Immunol. In Press. 

Levya-Castillo, M., Galand, C., Mashiko, S., Bissonnette, R., McGurk, A., Ziegler, S.F., Dong, C., McKenzie, A.N.J., Sarfati, M., Geha, R.S. ILC2 activation by keratinocyte-derived IL-25 promotes IL-13 production during allergic skin inflammation. J. All. Clin. Immunol. 145:1606-1614. 2020. PMID: 32179159. PMCID: PMC7282942. DOI: 10.1016/j.jaci.2020.02.026.

Levya-Castillo, J.M., Galand, C., Kam, C., Burton, O., Gurish, M., Goldsmith, J., Hait, E., Nurko, S., Brombacher, F., Dong, C., Finkelman, F.D., Lee, R.T., Ziegler, S., Austen, K.F., and Geha, R.S. Mechanical skin injury promotes food anaphylaxis by driving intestinal mast cell expansion. Immunity. 50:1262-1275, 2019. doi: 10.1016/j.immuni.2019.03.023. PMID 31027995.

 

Leyva-Castillo, J.M., Yoon, J., Geha, R.S. IL-22 promotes antigen driven airway inflammation in epicutaneously-sensitized mice. J. All. Clin. Immunol. 143:619-630, 2019. doi: 10.1016/j.jaci.2018.05.032. PMID: 29920352. PMCID: PMC6298864.

Malhotra, N., Leyva-Castillo, M., Jhadav, U., Barriero, O., Kam, C., O’Neill, N. K., Meylan, ., Chambon, P., von Andrian, U., Siegel , R., Wang, E., Shivdasani, R., Geha, R.S. Retinoic Acid Related Receptor Orphan Receptor a (RORa) expressing T regulatory cells restrain  type-2 cutaneous allergic inflammation. Science Immunology. 3: 21, 2018. pii: eaao6923. doi: 10.1126/sciimmunol.aao6923.
 

Malhotra, N., Yoon, J., Leyva-Castillo, J.M., Galand, C., Archer, N., Miller, L.S., and Geha, R.S. IL-22 released by TCRg/d cells restricts Staphylococcus aureus colonization of mechanically injured skin. J. All. Clin. Immunol  138(4):1098-1107, 2016.

Galand, C., Leyva-Castillo, J.M., Yoon, J., Han, A., Lee, M.S., McKenzie, A., Stassen, M., Oyoshi, M.K. and Geha, R.S. IL-33 promotes food anaphylaxis in epicutaneously sensitized mice by targeting mast cells. J. All. Clin. Immunol. 2016 Jun 2. pii: S0091-6749(16)30369-4. doi: 10.1016/j.jaci.2016.03.056.

Yoon, J., Kim H.Y#., Leyva-Castillo, M. #, Wang, G., Galand, C., Kumar, L., J.M., Leisten, S., Oyoshi, M., He, R., Terhorst, C., Chervonsky, A., Murphy, G., Oppenheim, J.J., Kuchroo, V.K., Umetsu, D.T., Malefyt, Rde, W., Van Den Brink, M.R., and Geha, R.S. Interleukin-23 induced by endogenous TLR4 ligands in keratinocytes programs skin dendritic cells to drive an IL-22 response to epicutaneous sensitization. J.Exp. Med. # Equal contribution 2016 Sep 19;213(10):2147-66. doi: 10.1084/jem.20150376.

Oyoshi, M., Lewis, C.N., Beaupre, J., Venturelli, N., Zeigler. S. McKenzie, A and Geha, R.S. IL-33 and TSLP promotes the dissemination of cutaneously inoculated vaccinia virus. J. All. Clin. Immunol.  135: 1511-18, 2015.

Bartnikas, L.M., M., Leisten, S., Janssen, E., Oettgen, H., Lewis, C. N., Austen, K.F., Gurish, M.F., Schulte, S., Hornick, S., Geha, R. S. * and M. Oyoshi.  Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food anaphylaxis. Equal contributing senior author. J. All. Clin. Immunol. 131: 451-460, 2013.

Oyoshi, M., He, R Li, Y., Mondal, S., Yoon, J., Afshar, R., Chen, M., Lee, D. M., Luo, H.R., Luster, A., Cho, J.S., Miller, L.S., Larson, A., Murphy, G. and R. S. Geha LTB4  driven neutrophil recruitment to the skin is essential for allergic skin inflammation. Immunity. 37:747-58, 2012.

Oyoshi, M., He, R., Kanaoka, Y., ElKhal, A., Kawamoto, S., Calamito, M., Lewis, C. N., Austen, K.F., and R. S. Geha. Eosinophil-derived LTC4 signals via CysLT2R to promote skin thickening and collagen deposition in a mouse model of allergic skin inflammation. Proc Natl Acad Sci U S A. 109:4992-7, 2012.

Oyoshi, M., ElKhal, A., Scott, J. E., Wurbel, M-A., Campbell J. and R. S. Geha Epicutaneous antigen challenge of orally sensitized mice  redirects antigen specific a4b7 gut homing T cells to the skin. J.  Clin. Investigation. 121: 2210-20, 2011.

Oyoshi, M., and R. S. Geha. Mechanical injury polarizes skin dendritic cells to elicit a Th2 response by inducing cutaneous TSLP expression. J. All. Clin. Immunol. 126: 976-984, 2010.

He, R., Oyoshi, M, Wang, JYT, Hodge, M., Jin, H., and Geha, R.S. The prostaglandin D2 receptor CRTH2 is important for allergic skin inflammation following epicutaneous antigen challenge.  J. All. Clin. Immunol. . 126: 784-790, 2010.

For a full list of Geha Lab publications